Journal of the American Chemical Society, 141(11), 4644-4652.In terms of game file size, you will need at least 512 MB of free disk space available. Fairbanks SD, Robertson CC, Keene FR, Thomas JA & Williamson MP (2019) Structural Investigation into the Threading Intercalation of a Chiral Dinuclear Ruthenium(II) Polypyridyl Complex through a B-DNA Oligonucleotide.Smith RE, Salamaga B, Szkuta P, Hajdamowicz N, Prajsnar TK, Bulmer GS, Fontaine T, Kołodziejczyk J, Herry J-M, Hounslow AM, Williamson MP et al (2019) Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system.Gonzalez-Delgado LS, Walters-Morgan H, Salamaga B, Robertson AJ, Hounslow AM, Jagielska E, Sabała I, Williamson MP, Lovering AL & Mesnage S (2019) Two-site recognition of Staphylococcus aureus peptidoglycan by lysostaphin SH3b.Fowler NJ, Sljoka A & Williamson MP (2020) A method for validating the accuracy of NMR protein structures.Southam HM, Williamson MP, Chapman JA, Lyon RL, Trevitt CR, Henderson PJF & Poole RK (2021) ‘Carbon-monoxide-releasing molecule-2 (CORM-2)’ is a misnomer: ruthenium toxicity, not CO release, accounts for Its antimicrobial effects.Fowler NJ, Sljoka A & Williamson MP (2021) The accuracy of NMR protein structures in the Protein Data Bank.Fowler NJ & Williamson MP (2022) The accuracy of protein structures in solution determined by AlphaFold and NMR.Hobbs B, Drant J & Williamson MP (2022) The measurement of binding affinities by NMR chemical shift perturbation.In methodology, I have worked in four main areas: Since then, I have worked both on NMR methodology and on determination of protein structures by NMR. This led to an interest in the NOE, where I worked first on 1D NOEs, showing that by using a viscous solvent you can make small molecules behave like bigger ones, and determined the definitive structure of vancomycin.Īround this time, Wüthrich was developing 2D NMR as a way of studying proteins, so after my PhD I got a research fellowship to work in his lab, where I was lucky enough to work on the first NMR structure of a globular protein (see his 2002 Nobel Prize lecture). 2015 Special invited professor, Kyoto University, Japanĭuring my PhD I used NMR to look at the structure and interactions of antibiotics mainly related to vancomycin, still a vital drug in the constant battle against bacterial drug resistance.2009 Visiting professor, Osaka University, Japan.2008-9 Visiting professor, Kinki University, Japan.1997 Japan Society for the Promotion of Science (JSPS) invitation fellow.
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